Mouse Anti-SMAD9 Recombinant Antibody (CBXS-2697) (CBMAB-S5449-CQ)

Name: Mouse Anti-SMAD9 Recombinant Antibody (CBXS-2697)
SKU: CBMAB-S5449-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-2697

Application

ELISA, WB

Immunogen

SMAD9 (NP_005896, 146aa-260aa) full length recombinant protein with GST tag

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SMAD9

Introduction

The protein encoded by this gene is a member of the SMAD family, which transduces signals from TGF-beta family members. The encoded protein is activated by bone morphogenetic proteins and interacts with SMAD4. Two transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

4093

UniProt ID

O15198

Alternative Names

SMAD Family Member 9; MAD Homolog 9; MADH6; MADH9; SMAD8; MAD, Mothers Against Decapentaplegic Homolog 9 (Drosophila); Mothers Against Decapentaplegic, Drosophila, Homolog Of, 9; SMAD, Mothers Against DPP Homolog 9 (Drosophila); Mothers Against Decapentaplegic Homolog 9;

Function

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).

Biological Process

Biological Process anatomical structure morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process BMP signaling pathwayISS:BHF-UCL
Biological Process cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to BMP stimulus1 PublicationNAS:BHF-UCL
Biological Process positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulusManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process SMAD protein signal transductionISS:BHF-UCL
Biological Process transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm
Nucleus
In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4 (By similarity).

Involvement in disease

Pulmonary hypertension, primary, 2 (PPH2):
A rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.

PTM

Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-SMAD9 Recombinant Antibody (3H2) (CAT#: CBMAB-S2848-CQ)

Mouse Anti-SMAD9 Monoclonal Antibody (2F4) (CAT#: CBMAB-0128-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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