Sign in or Register   Sign in or Register
  |  

Mouse Anti-SMARCA1 Recombinant Antibody (CBXS-3635) (CBMAB-S0917-CQ)

This product is a mouse antibody that recognizes SMARCA1. The antibody CBXS-3635 can be used for immunoassay techniques such as: ELISA, WB, IC, IP.
See all SMARCA1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-3635
Antibody Isotype
IgG1, κ
Application
ELISA, WB, IC, IP

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 1
Introduction
This gene encodes a member of the SWI/SNF family of proteins. The encoded protein is an ATPase which is expressed in diverse tissues and contributes to the chromatin remodeling complex that is involved in transcription. The protein may also play a role in DNA damage, growth inhibition and apoptosis of cancer cells. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
6594
UniProt ID
P28370
Alternative Names
ISWI; NURF140; SNF2L; SNF2L1; SNF2LB; SNF2LT; SWI; SWI2; hSNF2L
Function
Isoform 1
Catalytically inactive when either DNA or nucleosomes are the substrate and does not possess chromatin-remodeling activity (PubMed:15310751, PubMed:28801535).
Acts as a negative regulator of chromatin remodelers by generating inactive complexes (PubMed:15310751).
Isoform 2
Helicase that possesses intrinsic ATP-dependent chromatin-remodeling activity (PubMed:15310751, PubMed:14609955, PubMed:15640247, PubMed:28801535).
ATPase activity is substrate-dependent, and is increased when nucleosomes are the substrate, but is also catalytically active when DNA alone is the substrate (PubMed:15310751, PubMed:14609955, PubMed:15640247).
Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:15310751, PubMed:14609955, PubMed:15640247, PubMed:28801535).
Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template (PubMed:28801535).
Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes (PubMed:28801535).
The BAZ1A-, BAZ1B-, BAZ2A- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535).
The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535).
Within the NURF-1 and CERF-1 ISWI chromatin remodeling complexes, nucleosomes are the preferred substrate for its ATPase activity (PubMed:14609955, PubMed:15640247).
Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955).
May promote neurite outgrowth (PubMed:14609955).
May be involved in the development of luteal cells (PubMed:16740656).
Biological Process
Biological Process brain developmentManual Assertion Based On ExperimentIMP:HGNC-UCL
Biological Process chromatin remodelingManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process neuron differentiationISS:HGNC
Biological Process positive regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIMP:HGNC-UCL
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:HGNC-UCL
Biological Process regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIDA:ComplexPortal
Cellular Location
Nucleus
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-SMARCA1 Recombinant Antibody (CBXS-3635)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare