Mouse Anti-SMARCAL1 Monoclonal Antibody (1C4) (CBMAB-0129-LY)

Name: Mouse Anti-SMARCAL1 Monoclonal Antibody (1C4)
SKU: CBMAB-0129-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1C4

Application

IP, MA, WB

Immunogen

Recombinant peptide (Full Length)

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

SMARCAL1

Introduction

The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein shows sequence similarity to the E. coli RNA polymerase-binding protein HepA. ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks.

Entrez Gene ID

50485

UniProt ID

Q9NZC9

Alternative Names

HARP; HHARP

Function

ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks.

Biological Process

Biological Process cellular response to DNA damage stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process DNA repairManual Assertion Based On ExperimentIBA:GO_Central
Biological Process double-strand break repair via nonhomologous end joiningManual Assertion Based On ExperimentIMP:CACAO
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process replication fork processingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process replication fork protectionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process t-circle formationManual Assertion Based On ExperimentTAS:BHF-UCL

Cellular Location

Nucleus
Recruited to damaged DNA regions.

Involvement in disease

Schimke immuno-osseous dysplasia (SIOD):
An autosomal recessive pleiotropic disorder characterized by spondyloepiphyseal dysplasia, renal dysfunction and immunodeficiency. Arteriosclerosis may also occur in some case.

PTM

DNA damage-regulated phosphorylation by kinases that may include ATM, ATR and PRKDC.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-SMARCAL1 Monoclonal Antibody (1G2) (CAT#: CBMAB-0130-LY)

Mouse Anti-SMARCAL1 Monoclonal Antibody (1G7) (CAT#: CBMAB-0131-LY)

Rabbit Anti-SMARCAL1 Recombinant Antibody (CBXS-5385) (CAT#: CBMAB-S2598-CQ)

Rabbit Anti-SMARCAL1 Recombinant Antibody (CBXS-0539) (CAT#: CBMAB-S3483-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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