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Mouse Anti-SMARCD3 Recombinant Antibody (1G6) (CBMAB-A8356-LY)

The product is antibody recognizes SMARCD3. The antibody 1G6 immunoassay techniques such as: WB, ELISA.
See all SMARCD3 antibodies
Published Data
Fig.1 BAF60c proteins possess RAR-coactivating properties in HeLa and P19 cells.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
1G6
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
SMARCD3 (NP_001003801, 385 a.a. ~ 483 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
Introduction
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq]
Entrez Gene ID
6604
UniProt ID
Q6STE5
Alternative Names
BAF60C; CRACD3; MGC111010; Rsc6p
Function
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
Biological Process
Biological Process cardiac right ventricle formationIEA:Ensembl
Biological Process chromatin remodelingManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process muscle cell differentiationIEA:Ensembl
Biological Process nervous system developmentIEA:UniProtKB-KW
Biological Process neural retina developmentManual Assertion Based On ExperimentIEP:BHF-UCL
Biological Process nucleosome disassemblyManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of cell differentiation1 PublicationIC:ComplexPortal
Biological Process positive regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of double-strand break repair1 PublicationIC:ComplexPortal
Biological Process positive regulation of myoblast differentiation1 PublicationIC:ComplexPortal
Biological Process positive regulation of neuroblast proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of T cell differentiation1 PublicationIC:ComplexPortal
Biological Process regulation of G0 to G1 transition1 PublicationIC:ComplexPortal
Biological Process regulation of G1/S transition of mitotic cell cycle1 PublicationIC:ComplexPortal
Biological Process regulation of mitotic metaphase/anaphase transition1 PublicationIC:ComplexPortal
Biological Process regulation of nucleotide-excision repair1 PublicationIC:ComplexPortal
Biological Process regulation of protein bindingIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process secondary heart field specificationIEA:Ensembl
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

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