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Rabbit Anti-SMC4 Recombinant Antibody (CBXS-2378) (CBMAB-S5136-CQ)

This product is a rabbit antibody that recognizes SMC4. The antibody CBXS-2378 can be used for immunoassay techniques such as: IP, WB.
See all SMC4 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey, Mouse, Rat
Clone
CBXS-2378
Antibody Isotype
IgG
Application
IP, WB

Basic Information

Immunogen
Synthetic peptide corresponding to residues surrounding Tyr95 of human SMC4 (Q9NTJ3)
Specificity
Human, Monkey, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
10 mM sodium HEPES, pH 7.5, 150 mM sodium chloride, 0.1 mg/mL BSA, 50% glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Structural Maintenance Of Chromosomes 4
Introduction
This gene belongs to the 'structural maintenance of chromosomes' (SMC) gene family. Members of this gene family play a role in two changes in chromosome structure during mitotic segregation of chromosomes- chromosome condensation and sister chromatid cohesion. The protein encoded by this gene is likely a subunit of the 13S condensin complex, which is involved in chromosome condensation. A pseudogene related to this gene is located on chromosome 2.
Entrez Gene ID
Human10051
Mouse70099
Rat295107
Monkey702615
UniProt ID
HumanQ9NTJ3
MouseQ8CG47
RatF1MAD9
MonkeyI0FN73
Alternative Names
Structural Maintenance Of Chromosomes 4; Chromosome-Associated Polypeptide C; SMC Protein 4; SMC4L1; SMC-4; CAPC; SMC4 (Structural Maintenance Of Chromosomes 4, Yeast)-Like 1;
Function
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Biological Process
Biological Process cell divisionIEA:UniProtKB-KW
Biological Process kinetochore organizationIEA:Ensembl
Biological Process meiotic chromosome condensationIEA:Ensembl
Biological Process meiotic chromosome segregationIEA:Ensembl
Biological Process mitotic chromosome condensationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process mitotic sister chromatid segregationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process positive regulation of chromosome condensationManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process positive regulation of chromosome segregationIEA:Ensembl
Biological Process positive regulation of chromosome separationIEA:Ensembl
Cellular Location
Nucleus
Cytoplasm
Chromosome
In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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