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Mouse Anti-SMC6 Recombinant Antibody (CBXS-2020) (CBMAB-S4787-CQ)

This product is a mouse antibody that recognizes SMC6. The antibody CBXS-2020 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all SMC6 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBXS-2020
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Structural Maintenance Of Chromosomes 6
Introduction
SMC6 (Structural Maintenance Of Chromosomes 6) is a Protein Coding gene. Among its related pathways are SUMOylation and Metabolism of proteins.
Entrez Gene ID
Human79677
Mouse67241
Rat313961
UniProt ID
HumanQ96SB8
MouseQ924W5
RatA0A0G2JXU6
Alternative Names
Structural Maintenance Of Chromosomes 6; SMC Protein 6; SMC6L1; SMC-6; HSMC6; SMC6 Structural Maintenance Of Chromosomes 6-Like 1 (Yeast); SMC6 Structural Maintenance Of Chromosomes 6-Like 1; Structural Maintenance Of Chromosomes Protein 6;
Function
Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).
Biological Process
Biological Process cellular response to DNA damage stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular senescenceManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of chromosome segregationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein sumoylation1 PublicationIC:ComplexPortal
Biological Process regulation of telomere maintenance1 PublicationIC:ComplexPortal
Biological Process telomere maintenance via recombinationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus
Nucleus speckle
Chromosome
Nucleus, PML body
Chromosome, telomere
Colocalizes with SMC5 on the X-Y chromosome pair within the sex vesicle during late pachytene/diplotene (By similarity).
Localizes to PML nuclear bodies in ALT cell lines (PubMed:17589526).
Associates with chromatin (PubMed:25931565).
Accumulates with RAD18 and the SLF1-SLF2 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565).
Localizes in interchromatin granule clusters (PubMed:11408570).
PTM
Phosphorylated.
Sumoylated by NSMCE2/MMS21.
Ubiquitinated.
(Microbial infection) SMC5-SMC6 complex is degraded by the activity of Hepatitis B X protein.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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