Rabbit Anti-SMG1 Recombinant Antibody (CBXS-1518) (CBMAB-S4371-CQ)

Name: Rabbit Anti-SMG1 Recombinant Antibody (CBXS-1518)
SKU: CBMAB-S4371-CQ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Rabbit

Clone

CBXS-1518

Application

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SMG1, Nonsense Mediated MRNA Decay Associated PI3K Related Kinase

Introduction

This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined.

Entrez Gene ID

Human	23049
Mouse	233789
Rat	691397

UniProt ID

Human	Q96Q15
Mouse	Q8BKX6
Rat	A0A8I5ZMC8

Alternative Names

SMG1, Nonsense Mediated MRNA Decay Associated PI3K Related Kinase; SMG1 Phosphatidylinositol 3-Kinase-Related Kinase; Lambda/Iota Protein Kinase C-Interacting Protein; Lambda-Interacting Protein; EC 2.7.11.1; 61E3.4; LIP; ATX; Smg-1 Homolog, Phosphatidylinositol 3-Kinase-Related Kinase (C. Elegans);

Function

Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ.

Biological Process

Biological Process DNA repairIEA:UniProtKB-KW
Biological Process mRNA export from nucleusManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process negative regulation of macroautophagyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of response to DNA damage stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of telomere maintenanceManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process TOR signalingManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus
Cytoplasm
Present in the chromatoid body.

PTM

Autophosphorylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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