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Mouse Anti-SNAI2 Recombinant Antibody (62.1E6) (CBMAB-0262-CN)

This product is a mouse antibody that recognizes SNAI2 of chicken. The antibody 62.1E6 can be used for immunoassay techniques such as: ELISA.
See all SNAI2 antibodies

Summary

Host Animal
Mouse
Specificity
Chicken, Frog, Mouse
Clone
62.1E6
Antibody Isotype
IgG1, κ
Application
ELISA

Basic Information

Specificity
Chicken, Frog, Mouse
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Snail Family Transcriptional Repressor 2
Introduction
This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. SLUG plays a role in breast carcinoma as well as leukemia by downregulation of E-cadherin, which supports mesenchymal phenotype by shifting expression from a Type I to Type II cadherin profile.
Entrez Gene ID
Chicken432368
Mouse20583
Frog395065
UniProt ID
ChickenA0A1D5PVG0
MouseP97469
FrogQ91924
Alternative Names
SLUG
Function
Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity).
Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.
Biological Process
Biological Process aortic valve morphogenesisManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process cartilage morphogenesisIEA:Ensembl
Biological Process cell migration involved in endocardial cushion formationISS:BHF-UCL
Biological Process cellular response to epidermal growth factor stimulusManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process cellular response to ionizing radiationIEA:Ensembl
Biological Process desmosome disassemblyManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process endothelial cell migrationIEA:Ensembl
Biological Process epithelial to mesenchymal transitionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process epithelial to mesenchymal transition involved in endocardial cushion formationISS:BHF-UCL
Biological Process epithelium developmentBy SimilarityISS:BHF-UCL
Biological Process hematopoietic stem cell proliferationIEA:Ensembl
Biological Process myeloid cell apoptotic processIEA:Ensembl
Biological Process negative regulation of anoikisManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of cell adhesion involved in substrate-bound cell migrationIEA:Ensembl
Biological Process negative regulation of cell adhesion mediated by integrinManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of chondrocyte differentiationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of DNA damage response, signal transduction by p53 class mediatorManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of extrinsic apoptotic signaling pathway in absence of ligandBy SimilarityISS:BHF-UCL
Biological Process negative regulation of hematopoietic stem cell proliferationIEA:Ensembl
Biological Process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damageManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of keratinocyte proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of myeloid cell apoptotic processIEA:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of vitamin D biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of vitamin D receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process neural crest cell developmentManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process Notch signaling involved in heart developmentManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process Notch signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process osteoblast differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process pigmentationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of fat cell differentiationIEA:Ensembl
Biological Process positive regulation of histone acetylationIEA:Ensembl
Biological Process regulation of bicellular tight junction assemblyManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of branching involved in salivary gland morphogenesisIEA:Ensembl
Biological Process regulation of chemokine productionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of osteoblast differentiationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process roof of mouth developmentIEA:Ensembl
Biological Process sensory perception of soundManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process white fat cell differentiationIEA:Ensembl
Cellular Location
Nucleus
Cytoplasm
Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions.
Involvement in disease
Waardenburg syndrome 2D (WS2D):
WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1.
Piebald trait (PBT):
Autosomal dominant genetic developmental abnormality of pigmentation characterized by congenital patches of white skin and hair that lack melanocytes.
PTM
GSK3B-mediated phosphorylation results in cytoplasmic localization and degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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