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Rabbit Anti-SNAP23 Recombinant Antibody (CBXS-1607) (CBMAB-S4456-CQ)

This product is a rabbit antibody that recognizes SNAP23. The antibody CBXS-1607 can be used for immunoassay techniques such as: WB, IHC-P, IF.
See all SNAP23 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXS-1607
Antibody Isotype
IgG
Application
WB, IHC-P, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Synaptosome Associated Protein 23
Introduction
Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene.
Entrez Gene ID
8773
UniProt ID
O00161
Alternative Names
Synaptosome Associated Protein 23; Vesicle-Membrane Fusion Protein SNAP-23; Synaptosomal-Associated Protein, 23kDa; SNAP-23; Synaptosomal-Associated Protein, 23kD; Synaptosome Associated Protein 23kDa;
Function
Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.
Biological Process
Biological Process exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process histamine secretion by mast cellManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process membrane fusionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process post-Golgi vesicle-mediated transportManual Assertion Based On ExperimentTAS:ProtInc
Biological Process protein transportIEA:UniProtKB-KW
Biological Process synaptic vesicle fusion to presynaptic active zone membraneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process synaptic vesicle primingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle fusionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle targetingManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Cell membrane
Synapse, synaptosome
Mainly localized to the plasma membrane.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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