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Mouse Anti-SNRPD3 Recombinant Antibody (CBXS-4674) (CBMAB-S1909-CQ)

This product is a mouse antibody that recognizes SNRPD3. The antibody CBXS-4674 can be used for immunoassay techniques such as: WB.
See all SNRPD3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4674
Antibody Isotype
IgG2a
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 1% BSA
Preservative
0.05% sodium azide
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Small Nuclear Ribonucleoprotein D3 Polypeptide
Introduction
This gene encodes a core component of the spliceosome, which is a nuclear ribonucleoprotein complex that functions in pre-mRNA splicing. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
6634
UniProt ID
P62318
Alternative Names
Small Nuclear Ribonucleoprotein D3 Polypeptide; Small Nuclear Ribonucleoprotein D3 Polypeptide 18kDa; SnRNP Core Protein D3; Sm-D3; Small Nuclear Ribonucleoprotein D3 Polypeptide (18kD); Small Nuclear Ribonucleoprotein Sm D3; SMD3;
Function
Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346).
Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346).
Is also a component of the minor U12 spliceosome (PubMed:15146077).
As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity).
Biological Process
Biological Process 7-methylguanosine cap hypermethylation1 PublicationIC:ComplexPortal
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein methylationManual Assertion Based On ExperimentIDA:MGI
Biological Process RNA splicingManual Assertion Based On ExperimentTAS:ProtInc
Biological Process spliceosomal snRNP assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process U2-type prespliceosome assembly1 PublicationIC:ComplexPortal
Cellular Location
Cytoplasm, cytosol
Nucleus
SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
PTM
Methylated on arginine residues by PRMT5 and PRMT7; probable asymmetric dimethylation which is required for assembly and biogenesis of snRNPs.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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