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Mouse Anti-SNRPG Recombinant Antibody (2H8-1C12) (CBMAB-A8427-LY)

The product is antibody recognizes SNRPG. The antibody 2H8-1C12 immunoassay techniques such as: WB, ELISA.
See all SNRPG antibodies
Published Data
Fig.1 Genetic screening identifies knockdown of SMG-1 in development of sorafenib resistance.
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Fig.2 SMG-1 suppression induces sorafenib resistance in Hep3B cells.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
2H8-1C12
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
SNRPG (AAH00070, 1 a.a. ~ 76 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
small nuclear ribonucleoprotein polypeptide G
Entrez Gene ID
6637
UniProt ID
P62308
Alternative Names
MGC117317; SMG
Function
Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346).
Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346).
Is also a component of the minor U12 spliceosome (PubMed:15146077).
As part of the U7 snRNP it is involved in histone 3'-end processing (PubMed:12975319).
Biological Process
Biological Process 7-methylguanosine cap hypermethylation1 PublicationIC:ComplexPortal
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process RNA splicingManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process spliceosomal complex assembly1 PublicationNAS:UniProtKB
Biological Process spliceosomal snRNP assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process U2-type prespliceosome assembly1 PublicationIC:ComplexPortal
Cellular Location
Cytoplasm, cytosol
Nucleus
SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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