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Mouse Anti-SNX13 Recombinant Antibody (CBCNS-001) (CBMAB-R4014-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNS-001
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Sorting Nexin 13
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 50% Glycerol
Preservative
0.02% Sodium azide
Concentration
0.5 mg/mL

Target

Full Name
Sorting Nexin 13
Introduction
This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq, Jul 2008]
Entrez Gene ID
23161
UniProt ID
Q9Y5W8
Alternative Names
Sorting Nexin 13; RGS-PX1; Rgs Domain- And Phox Domain-Containing Protein; RGS Domain- And PHOX Domain-Containing Protein; Sorting Nexin-13; KIAA0713;
Function
May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis (By similarity).
Acts as a GAP for Galphas.
Biological Process
Biological Process intracellular protein transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of signal transductionIEA:UniProtKB-KW
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Early endosome membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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