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Mouse Anti-SNX27 Recombinant Antibody (CBXS-3931) (CBMAB-S1196-CQ)

This product is a mouse antibody that recognizes SNX27. The antibody CBXS-3931 can be used for immunoassay techniques such as: WB, ELISA, IP, IF.
See all SNX27 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse
Clone
CBXS-3931
Antibody Isotype
IgG1
Application
WB, ELISA, IP, IF

Basic Information

Immunogen
Full length for SNX27 protein
Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sorting Nexin Family Member 27
Introduction
This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.
Entrez Gene ID
76742
UniProt ID
Q3UHD6
Alternative Names
5730552M22Rik; ESTM45; ESTM47; R75405
Function
Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes.
Biological Process
Biological Process endocytic recyclingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endosomal transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endosome to lysosome transportIEA:Ensembl
Biological Process establishment of natural killer cell polarityManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process signal transductionIEA:InterPro
Cellular Location
Early endosome membrane
Cytoplasm, cytosol
Localizes to immunological synapse in T-cells. In T-cells, recruited from the cytosol to sorting endosomes by phosphoinositide-3-kinase products.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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