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Mouse Anti-SNX3 Recombinant Antibody (CBXS-0625) (CBMAB-S3566-CQ)

This product is a mouse antibody that recognizes SNX3. The antibody CBXS-0625 can be used for immunoassay techniques such as: ELISA, WB.
See all SNX3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0625
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
SNX3 (AAH16863, 1 a.a.-113 a.a) Full length recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
sorting nexin 3
Introduction
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking. A pseudogene of this gene is present on the sex chromosomes. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Entrez Gene ID
8724
UniProt ID
O60493
Alternative Names
Sorting Nexin 3; Sorting Nexin 3A; Sorting Nexin-3; Protein SDP3; MCOPS8; Grd19; SDP3;
Function
Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Can also bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (By similarity).
Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:21725319, PubMed:24344282, PubMed:30213940).
Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity).
Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes (PubMed:23237080).
Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex (By similarity).
In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs (PubMed:20482551).
Biological Process
Biological Process endocytic recyclingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process intralumenal vesicle formationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process late endosome to Golgi transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process membrane invaginationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of early endosome to late endosome transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of phagocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of protein transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of viral entry into host cellManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of neuron projection developmentISS:UniProtKB
Biological Process protein to membrane dockingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein transportIEA:UniProtKB-KW
Biological Process regulation of Wnt signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process response to bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Early endosome
Cytoplasmic vesicle, phagosome
Colocalizes to clathrin-coated endosomal vesicles morphologically distinct from retromer-decorated non-branched endosomal tubule structures (PubMed:21725319) Colocalizes with EEA1 on nascent phagosomes in dendritic cells but competes with EEA1 for binding to phagosomal membrane (PubMed:23237080).
In the case of Salmonella enterica infection localizes to Salmonella-containing vacuoles (SCVs) from which SNX3-containing tubules form 30-60 min after infection (PubMed:20482551).
Involvement in disease
A chromosomal aberration involving SNX3 has been found in patients with syndromic microphthalmia. Translocation t(6;13)(q21;q12).
PTM
Ubiquitinated, leading to its proteasomal degradation. Deubiquitinated by USP10 (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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