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Mouse Anti-SOCS4 Recombinant Antibody (CBXS-1846) (CBMAB-S4649-CQ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBXS-1846
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Recombinant human SOCS-4, Met1-Cys440, Accession # Q8WXH5
Specificity
Human, Mouse
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
suppressor of cytokine signaling 4
Introduction
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
Entrez Gene ID
Human122809
Mouse67296
UniProt ID
HumanQ8WXH5
MouseQ91ZA6
Alternative Names
Suppressor Of Cytokine Signaling 4; Suppressor Of Cytokine Signaling 7; SOCS-4; SOCS-7; SOCS7; SH2 Domain Containing SOCS Box Protein;
Function
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.
Biological Process
Biological Process intracellular signal transductionIEA:InterPro
Biological Process negative regulation of epidermal growth factor-activated receptor activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic processIEA:InterPro
Biological Process protein ubiquitinationIEA:UniProtKB-UniPathway
Cellular Location
Phosphatidylinositol 3-kinase complex
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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