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Mouse Anti-SOCS7 Recombinant Antibody (CBXS-1848) (CBMAB-S4651-CQ)

This product is a mouse antibody that recognizes SOCS7. The antibody CBXS-1848 can be used for immunoassay techniques such as: WB.
See all SOCS7 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-1848
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Recombinant human SOCS-7, His351-Thr581, Accession # O14512
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Suppressor Of Cytokine Signaling 7
Introduction
SOCS7 (Suppressor Of Cytokine Signaling 7) is a Protein Coding gene. Among its related pathways are Jak-STAT signaling pathway (KEGG) and Jak/STAT Signaling Pathway Intracellular Regulation. Gene Ontology (GO) annotations related to this gene include SH3 domain binding and protein kinase inhibitor activity. An important paralog of this gene is SOCS6.
Entrez Gene ID
30837
UniProt ID
O14512
Alternative Names
Suppressor Of Cytokine Signaling 7; NCK-Associated Protein 4; Nck, Ash And Phospholipase C Gamma-Binding Protein; Nck, Ash And Phospholipase C Binding Protein; SOCS-7; NAP-4; NAP4; NCKAP4; SOCS6;
Function
Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Biological Process
Biological Process intracellular signal transductionIEA:InterPro
Biological Process negative regulation of signal transductionIEA:UniProtKB-KW
Biological Process phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein ubiquitinationIEA:UniProtKB-UniPathway
Cellular Location
Cytoplasm
Cell membrane
Nucleus
Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus after UV irradiation. Cytoplasmic location depends upon SEPT7 presence.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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