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Mouse Anti-SORCS2 Recombinant Antibody (CBXS-2749) (CBMAB-S5500-CQ)

This product is a mouse antibody that recognizes SORCS2. The antibody CBXS-2749 can be used for immunoassay techniques such as: ELISA, WB.
See all SORCS2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2749
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa802-901 from human SORCS2 (NP_065828) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
sortilin-related VPS10 domain containing receptor 2
Introduction
This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system.
Entrez Gene ID
57537
UniProt ID
Q96PQ0
Alternative Names
Sortilin Related VPS10 Domain Containing Receptor 2; Sortilin-Related VPS10 Domain Containing Receptor 2; KIAA1329;
Function
The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF) (PubMed:22155786, PubMed:24908487).
ProNGF and proBDNF binding both promote axon growth cone collapse (in vitro) (PubMed:22155786, PubMed:24908487).
Plays a role in the regulation of dendritic spine density in hippocampus neurons (By similarity).
Required for normal neurite branching and extension in response to BDNF (PubMed:27457814).
Plays a role in BDNF-dependent hippocampal synaptic plasticity. Together with NGFR and NTRK2, is required both for BDNF-mediated synaptic long-term depression and long-term potentiation (PubMed:27457814).
ProNGF binding promotes dissociation of TRIO from the heterodimer, which leads to inactivation of RAC1 and/or RAC2 and subsequent reorganization of the actin cytoskeleton (PubMed:22155786).
Together with the retromer complex subunit VPS35, required for normal expression of GRIN2A at synapses and dendritic cell membranes. Required for normal expression of the amino acid transporter SLC1A1 at the cell membrane, and thereby contributes to protect cells against oxidative stress (By similarity).
SorCS2 122 kDa chain
Does not promote Schwann cell apoptosis in response to proBDNF.
SorCS2 104 kDa chain and SorCS2 18 kDa chain together promote Schwann cell apoptosis in response to proBDNF.
Biological Process
Biological Process intracellular protein transportIEA:Ensembl
Biological Process long-term synaptic depressionIEA:Ensembl
Biological Process neuropeptide signaling pathway1 PublicationNAS:UniProtKB
Cellular Location
Cell membrane
Cell projection
Cytoplasmic vesicle membrane
Early endosome membrane
Recycling endosome membrane
Synapse, synaptosome
Perikaryon
Cell projection, dendrite
Cell projection, dendritic spine
Postsynaptic density membrane
Topology
Extracellular: 51-1078
Helical: 1079-1099
Cytoplasmic: 1100-1159
PTM
Proteolytic cleavage removes a propeptide, giving rise to a 122 kDa chain that includes a cytoplasmic tail. Further cleavage gives rise to a 104 kDa chain that lacks the cytoplasmic tail, and a membrane-bound 18 kDa chain. The 104 kDa chain remains bound to the 18 kDa chain.
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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