Mouse Anti-SORD Recombinant Antibody (1C2) (CBMAB-A8457-LY)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. The polyol pathway is believed to be involved in the etiology of diabetic complications, such as diabetic neuropathy and retinopathy, induced by hyperglycemia (PubMed:12962626, PubMed:29966615, PubMed:25105142).
May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (PubMed:16278369).
May have a more general function in the metabolism of secondary alcohols since it also catalyzes the stereospecific oxidation of (2R,3R)-2,3-butanediol. To a lesser extent, can also oxidize L-arabinitol, galactitol and D-mannitol and glycerol in vitro. Oxidizes neither ethanol nor other primary alcohols. Cannot use NADP+ as the electron acceptor (PubMed:3365415).
Biological Process fructose biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process glucose metabolic processManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process glucuronate catabolic process to xylulose 5-phosphateIEA:Ensembl
Biological Process L-xylitol catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process L-xylitol metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to cadmium ionIEA:Ensembl
Biological Process response to copper ionIEA:Ensembl
Biological Process response to hormoneIEA:Ensembl
Biological Process response to nutrient levelsIEA:Ensembl
Biological Process response to osmotic stressIEA:Ensembl
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process sorbitol catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Cell projection, cilium, flagellum
Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface.
An autosomal recessive disorder characterized by motor axonal neuropathy, slowly progressive distal muscle weakness mainly affecting the lower limbs, difficulty walking, and increased serum sorbitol. Additional variable features are distal sensory impairment, upper limb tremor, scoliosis, and mild hearing loss.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
Antibody Pairs
SORD Matched Antibody Pair (1122) (CAT#: APMAB-1122LY)
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SORD Matched Antibody Pair (1122) (CAT#: APMAB-1122LY)
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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