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Mouse Anti-SOX6 Monoclonal Antibody (667136) (CBMAB-1525-YC)

Provided herein is a mouse monoclonal antibody against Human SOX6. The antibody, clone 667136, can be used for immunoassay techniques, such as ICC.
See all SOX6 antibodies
Published Data
Fig.1 SOX6 protein level in ovarian carcinoma tissues and matched non-tumor tissues.
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Fig.2 Overexpression of SOX6 in PA-1 and SW626 cells by stable transfection.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
667136
Antibody Isotype
IgG2a
Application
ICC

Basic Information

Immunogen
E. coli-derived recombinant human SOX6 Met1-Leu339.
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SRY-Box 6
Introduction
SOX6 is a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. SOX6 is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells.
Entrez Gene ID
55553
UniProt ID
P35712
Alternative Names
SOXD; HSSOX6
Function
Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (Probable). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity).
Biological Process
Biological Process brain developmentManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cartilage condensationISS:UniProtKB
Biological Process cartilage developmentISS:UniProtKB
Biological Process cell fate commitmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to transforming growth factor beta stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process central nervous system developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process chondrocyte differentiationISS:UniProtKB
Biological Process muscle organ development1 PublicationNAS:UniProtKB
Biological Process negative regulation of cardiac muscle cell differentiationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of cartilage developmentManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of chondrocyte differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of mesenchymal stem cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of DNA-templated transcription1 PublicationNAS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process spinal cord oligodendrocyte cell differentiationISS:UniProtKB
Cellular Location
Nucleus
Cytoplasm
Involvement in disease
Tolchin-Le Caignec syndrome (TOLCAS):
An autosomal dominant disorder characterized by mildly to moderately impaired intellectual development and behavioral problems, such as autism, attention deficit and hyperactivity disorder, and aggressive episodes. Highly variable, additional features include osteochondroma, craniosynostosis, dysmorphic facies, arachnodactyly, and large head circumference.
PTM
Sumoylation inhibits the transcriptional activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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