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Mouse Anti-SPAG4 Recombinant Antibody (CBXS-4820) (CBMAB-S2045-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4820
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
sperm associated antigen 4
Introduction
The mammalian sperm flagellum contains two cytoskeletal structures associated with the axoneme: the outer dense fibers surrounding the axoneme in the midpiece and principal piece and the fibrous sheath surrounding the outer dense fibers in the principal piece of the tail. Defects in these structures are associated with abnormal tail morphology, reduced sperm motility, and infertility. In the rat, the protein encoded by this gene associates with an outer dense fiber protein via a leucine zipper motif and localizes to the microtubules of the manchette and axoneme during sperm tail development. Alternative splicing results in multiple transcript variants encoding different isoforms.
Entrez Gene ID
6676
UniProt ID
Q9NPE6
Alternative Names
Sperm Associated Antigen 4; Outer Dense Fiber-Associated Protein SPAG4; Sad1 And UNC84 Domain Containing 4; SUN Domain-Containing Protein 4; Cancer/Testis Antigen 127; Acrosomal Protein ACR55;
Function
Involved in spermatogenesis. Required for sperm head formation but not required to establish and maintain general polarity of the sperm head. Required for anchoring and organization of the manchette. Required for targeting of SUN3 and probably SYNE1 through a probable SUN1:SYNE3 LINC complex to the nuclear envelope and involved in accurate posterior sperm head localization of the complex. May anchor SUN3 the nuclear envelope. Involved in maintenance of the nuclear envelope integrity. May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail.
Biological Process
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process nuclear envelope organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process spermatogenesisManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Membrane
Cytoplasm, cytoskeleton
Cytoplasm, cytoskeleton, flagellum axoneme
Nucleus envelope
Nucleus inner membrane
In spermatids, it is localized in the transient manchette and in the axoneme of elongating spermatids and epididymal sperm (By similarity).
Colocalized with SEPT12 at the nuclear periphery in round spermatids, at sperm neck in elongated spermatids and at midpiece regions in ejaculated spermatozoa (PubMed:25775403).
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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