Mouse Anti-SPAG6 Recombinant Antibody (CBXS-2391) (CBMAB-S5149-CQ)

Name: Mouse Anti-SPAG6 Recombinant Antibody (CBXS-2391)
SKU: CBMAB-S5149-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-2391

Application

Immunogen

Recombinant protein corresponding to a portion of amino acids within aa1-101 of human SPAG6 with a GST Tag

Specificity

Human

Antibody Isotype

IgG3, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

sperm associated antigen 6

Introduction

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

9576

UniProt ID

O75602

Alternative Names

Sperm Associated Antigen 6; Axoneme Central Apparatus Protein; Sperm Flagellar Protein; Protein PF16 Homolog; Repro-SA-1; Pf16; Testicular Tissue Protein Li 176; Sperm-Associated Antigen 6; CT141;

Function

Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility.

Biological Process

Biological Process cilium movementManual Assertion Based On ExperimentIBA:GO_Central
Biological Process epithelial cilium movement involved in extracellular fluid movementManual Assertion Based On ExperimentIBA:GO_Central
Biological Process filopodium assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neuron projection extensionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sperm axoneme assemblyManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm, cytoskeleton
Cell projection, cilium, flagellum
Cytoplasm, cytoskeleton, cilium axoneme
Associated with microtubules. Detected on the sperm flagellum (PubMed:10493827).
Localizes in the cilium axoneme in a SPEF1-dependent manner (By similarity).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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