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Mouse Anti-SPAG6 Recombinant Antibody (CBXS-2391) (CBMAB-S5149-CQ)

This product is a mouse antibody that recognizes SPAG6. The antibody CBXS-2391 can be used for immunoassay techniques such as: WB.
See all SPAG6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2391
Antibody Isotype
IgG3, κ
Application
WB

Basic Information

Immunogen
Recombinant protein corresponding to a portion of amino acids within aa1-101 of human SPAG6 with a GST Tag
Specificity
Human
Antibody Isotype
IgG3, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
sperm associated antigen 6
Introduction
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
9576
UniProt ID
O75602
Alternative Names
Sperm Associated Antigen 6; Axoneme Central Apparatus Protein; Sperm Flagellar Protein; Protein PF16 Homolog; Repro-SA-1; Pf16; Testicular Tissue Protein Li 176; Sperm-Associated Antigen 6; CT141;
Function
Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility.
Biological Process
Biological Process cilium movementManual Assertion Based On ExperimentIBA:GO_Central
Biological Process epithelial cilium movement involved in extracellular fluid movementManual Assertion Based On ExperimentIBA:GO_Central
Biological Process filopodium assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neuron projection extensionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sperm axoneme assemblyManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm, cytoskeleton
Cell projection, cilium, flagellum
Cytoplasm, cytoskeleton, cilium axoneme
Associated with microtubules. Detected on the sperm flagellum (PubMed:10493827).
Localizes in the cilium axoneme in a SPEF1-dependent manner (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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