Rabbit Anti-SPATA5 Recombinant Antibody (CBXS-1369) (CBMAB-S4227-CQ)

Name: Rabbit Anti-SPATA5 Recombinant Antibody (CBXS-1369)
SKU: CBMAB-S4227-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

CBXS-1369

Application

WB, FC

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Spermatogenesis Associated 5

Introduction

This gene encodes a member of the ATPase associated with diverse activities family, whose members are defined by a highly conserved ATPase domain. Members of this family participate in diverse cellular processes that include membrane fusion, DNA replication, microtubule severing, and protein degradation. The protein encoded by this gene has a putative mitochondrial targeting sequence and has been proposed to function in maintenance of mitochondrial function and integrity during mouse spermatogenesis. Allelic variants in this gene have been associated with epilepsy, hearing loss, and cognitive disability syndrome. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

166378

UniProt ID

Q8NB90

Alternative Names

Spermatogenesis Associated 5; Spermatogenesis-Associated Factor Protein; ATPase Family Protein 2 Homolog; AFG2; SPAF; ATPase Family Gene 2 Homolog (S. Cerevisiae);

Function

ATP-dependent chaperone, which plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024).
Acts together with SPATA5L1, C1orf109 and CINP (PubMed:35354024).
May be involved in morphological and functional mitochondrial transformations during spermatogenesis (By similarity).

Biological Process

Biological Process brain developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process ribosomal large subunit biogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process spermatogenesisIEA:UniProtKB-KW

Cellular Location

Cytoplasm
Mitochondrion
Cytoplasm, cytoskeleton, spindle

Involvement in disease

Neurodevelopmental disorder with hearing loss, seizures, and brain abnormalities (NEDHSB):
An autosomal recessive disorder characterized by intellectual disability, intractable epilepsy, microcephaly, abnormal muscle tone, and sensorineural hearing loss.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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