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Rabbit Anti-SPATA5 Recombinant Antibody (CBXS-1369) (CBMAB-S4227-CQ)

This product is a rabbit antibody that recognizes SPATA5. The antibody CBXS-1369 can be used for immunoassay techniques such as: WB, FC.
See all SPATA5 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXS-1369
Antibody Isotype
IgG
Application
WB, FC

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Spermatogenesis Associated 5
Introduction
This gene encodes a member of the ATPase associated with diverse activities family, whose members are defined by a highly conserved ATPase domain. Members of this family participate in diverse cellular processes that include membrane fusion, DNA replication, microtubule severing, and protein degradation. The protein encoded by this gene has a putative mitochondrial targeting sequence and has been proposed to function in maintenance of mitochondrial function and integrity during mouse spermatogenesis. Allelic variants in this gene have been associated with epilepsy, hearing loss, and cognitive disability syndrome. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
166378
UniProt ID
Q8NB90
Alternative Names
Spermatogenesis Associated 5; Spermatogenesis-Associated Factor Protein; ATPase Family Protein 2 Homolog; AFG2; SPAF; ATPase Family Gene 2 Homolog (S. Cerevisiae);
Function
ATP-dependent chaperone, which plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024).
Acts together with SPATA5L1, C1orf109 and CINP (PubMed:35354024).
May be involved in morphological and functional mitochondrial transformations during spermatogenesis (By similarity).
Biological Process
Biological Process brain developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process ribosomal large subunit biogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process spermatogenesisIEA:UniProtKB-KW
Cellular Location
Cytoplasm
Mitochondrion
Cytoplasm, cytoskeleton, spindle
Involvement in disease
Neurodevelopmental disorder with hearing loss, seizures, and brain abnormalities (NEDHSB):
An autosomal recessive disorder characterized by intellectual disability, intractable epilepsy, microcephaly, abnormal muscle tone, and sensorineural hearing loss.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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