Rabbit Anti-SPC24 Recombinant Antibody (CBXS-1284) (CBMAB-S4143-CQ)

Name: Rabbit Anti-SPC24 Recombinant Antibody (CBXS-1284)
SKU: CBMAB-S4143-CQ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Rabbit

Clone

CBXS-1284

Application

WB, IP, IF

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SPC24, NDC80 Kinetochore Complex Component

Introduction

SPC24 (SPC24, NDC80 Kinetochore Complex Component) is a Protein Coding gene. Among its related pathways are Signaling by Rho GTPases and Cell Cycle, Mitotic.

Entrez Gene ID

147841

UniProt ID

Q8NBT2

Alternative Names

SPC24, NDC80 Kinetochore Complex Component; SPBC24; HSpc24; SPC24, NDC80 Kinetochore Complex Component, Homolog (S. Cerevisiae); Spindle Pole Body Component 24 Homolog (S. Cerevisiae); SPC24, NDC80 Kinetochore Complex Component, Homolog; Spindle Pole Body Component 24 Homolog; Kinetochore Protein Spc24;

Function

Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14738735).
Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735).
The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).

Biological Process

Biological Process attachment of spindle microtubules to kinetochoreManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process cell divisionIEA:UniProtKB-KW
Biological Process chromosome segregationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mitotic spindle assembly checkpoint signaling1 PublicationIC:ComplexPortal

Cellular Location

Nucleus
Chromosome, centromere, kinetochore
Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Rabbit Anti-SPC24 Recombinant Antibody (CBXS-1285) (CAT#: CBMAB-S4144-CQ)

Mouse Anti-SPC24 Recombinant Antibody (CBXS-4330) (CAT#: CBMAB-S1575-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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