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Mouse Anti-SPEF2 (AA 324-423) Recombinant Antibody (CBXS-0685) (CBMAB-S3622-CQ)

This product is a mouse antibody that recognizes SPEF2. The antibody CBXS-0685 can be used for immunoassay techniques such as: ELISA, IF, WB.
See all SPEF2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0685
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 324-423

Target

Full Name
Sperm Flagellar 2
Introduction
SPEF2 (Sperm Flagellar 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein dimerization activity.
Entrez Gene ID
79925
UniProt ID
Q9C093
Alternative Names
Sperm Flagellar 2; Cancer/Testis Antigen 122; KPL2; Testis Tissue Sperm-Binding Protein Li 47a; Sperm Flagellar Protein 2; Protein KPL2; KIAA1770; CT122;
Function
Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis (PubMed:31278745, PubMed:31151990, PubMed:31048344).
Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation (By similarity).
Biological Process
Biological Process brain morphogenesisISS:UniProtKB
Biological Process epithelial cilium movement involved in extracellular fluid movementISS:UniProtKB
Biological Process respiratory system developmentISS:UniProtKB
Biological Process skeletal system morphogenesisISS:UniProtKB
Biological Process sperm axoneme assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process spermatogenesisISS:UniProtKB
Cellular Location
Cell projection, cilium, flagellum
Cytoplasm
Golgi apparatus
Shows dynamic localization in developing spermatozoa. Localizes to the manchette in step 10-12 elongating spermatids. Detected in the basal body and neck area of step 13-14 spermatids. Localizes to the midpiece of the sperm tail in step 15-16 spermatids. During the epididymal transport of spermatozoa, expression in the sperm tail reduces and becomes concentrated at the distal part of the midpiece. Detected in the Golgi apparatus of late spermatocytes and round spermatids. Detected in the cytoplasm of Sertoli cells.
Involvement in disease
Spermatogenic failure 43 (SPGF43):
An autosomal recessive infertility disorder characterized by asthenospermia due to multiple morphologic abnormalities of sperm flagella, including short, absent, coiled, and bent flagella.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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