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Rabbit Anti-SPESP1 Recombinant Antibody (CBXS-1249) (CBMAB-S4108-CQ)

This product is a rabbit antibody that recognizes SPESP1. The antibody CBXS-1249 can be used for immunoassay techniques such as: WB.
See all SPESP1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXS-1249
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sperm Equatorial Segment Protein 1
Introduction
The encoded protein is a human alloantigen involved in sperm-egg binding and fusion.
Entrez Gene ID
246777
UniProt ID
Q6UW49
Alternative Names
Sperm Equatorial Segment Protein 1; Glycosylated 38 KDa Sperm Protein C-7/8; Equatorial Segment Protein; SP-ESP; ESP;
Function
Involved in fertilization ability of sperm.
Biological Process
Biological Process acrosome reactionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process fertilizationISS:UniProtKB
Biological Process fusion of sperm to egg plasma membrane involved in single fertilizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sperm-egg recognitionISS:UniProtKB
Cellular Location
Cytoplasmic vesicle, secretory vesicle, acrosome
Small proacrosomal granules (during the Golgi phase), enlarged acrosomal vesicles (during the cap phase), acrosome (during the elongating phase), equatorial segment of the acrosome (during the maturation phase) (PubMed:12773409).
After acrosome reaction localizes to the equatorial segment region in both noncapacitated and capacitated, acrosome-reacted sperm (By similarity).
PTM
Glycosylated. In testis there are two predominant forms of 77- and 67-kDa and a form of 47-kDa, whereas in epididymal sperm from caput, corpus, and cauda there are two forms of 47- and 43-kDa. Testis forms contain complex carbohydrate residues. Epididymal sperm forms are N-glycosylated. Then undergoes significant glycosylation in the testis and that the majority of these glycoconjugates are removed by the time sperm reach the caput epididymis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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