Rabbit Anti-SPESP1 Recombinant Antibody (CBXS-1249) (CBMAB-S4108-CQ)

Name: Rabbit Anti-SPESP1 Recombinant Antibody (CBXS-1249)
SKU: CBMAB-S4108-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

CBXS-1249

Application

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Sperm Equatorial Segment Protein 1

Introduction

The encoded protein is a human alloantigen involved in sperm-egg binding and fusion.

Entrez Gene ID

246777

UniProt ID

Q6UW49

Alternative Names

Sperm Equatorial Segment Protein 1; Glycosylated 38 KDa Sperm Protein C-7/8; Equatorial Segment Protein; SP-ESP; ESP;

Function

Involved in fertilization ability of sperm.

Biological Process

Biological Process acrosome reactionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process fertilizationISS:UniProtKB
Biological Process fusion of sperm to egg plasma membrane involved in single fertilizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sperm-egg recognitionISS:UniProtKB

Cellular Location

Cytoplasmic vesicle, secretory vesicle, acrosome
Small proacrosomal granules (during the Golgi phase), enlarged acrosomal vesicles (during the cap phase), acrosome (during the elongating phase), equatorial segment of the acrosome (during the maturation phase) (PubMed:12773409).
After acrosome reaction localizes to the equatorial segment region in both noncapacitated and capacitated, acrosome-reacted sperm (By similarity).

PTM

Glycosylated. In testis there are two predominant forms of 77- and 67-kDa and a form of 47-kDa, whereas in epididymal sperm from caput, corpus, and cauda there are two forms of 47- and 43-kDa. Testis forms contain complex carbohydrate residues. Epididymal sperm forms are N-glycosylated. Then undergoes significant glycosylation in the testis and that the majority of these glycoconjugates are removed by the time sperm reach the caput epididymis.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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