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Recombinant Mouse Anti-SPLUNC1 Antibody (CBHb329) (CBMAB-Hb992-LY)

The product is antibody recognizes SPLUNC1. The antibody CBHb329 immunoassay techniques such as: IHC-F, Immuno assays, IF, WB.
See all SPLUNC1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBHb329
Antibody Isotype
IgG1
Application
IHC-F, Immuno assays, IF, WB

Basic Information

Immunogen
Recombinant SPLUNC1
Specificity
Human, Mouse
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1% BSA
Preservative
0.02% sodium azide
Concentration
0.1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Bpi Fold Containing Family A Member 1
Entrez Gene ID
Human51297
Mouse18843
UniProt ID
HumanQ9NP55
MouseP97361
Alternative Names
LUNX, NASG, PLUNC, BPI fold-containing family A member 1, SPURT, Lung-specific protein X, Nasopharyngeal carcinoma-related protein, Palate lung and nasal epithelium clone protein, Secretory protein in upper respiratory tracts, Short PLUNC1, Tracheal epithelium-enriched protein, Von Ebner protein Hl
Function
Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC) (PubMed:25223608).
Plays a role in the innate immune responses of the upper airways (PubMed:23499554, PubMed:23132494).
Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae (PubMed:23499554, PubMed:23132494, PubMed:27145151).
Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus (PubMed:24124190, PubMed:24043776).
Plays a role in the airway inflammatory response after exposure to irritants (PubMed:11425234).
May attract macrophages and neutrophils (PubMed:23132494).
Biological Process
Antibacterial humoral response Source: UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Antimicrobial humoral response Source: Reactome
Defense response to virus Source: UniProtKB
Immune response in nasopharyngeal-associated lymphoid tissue Source: UniProtKB
Innate immune response Source: UniProtKB
Multicellular organismal water homeostasis Source: UniProtKB
Negative regulation of single-species biofilm formation in or on host organism Source: UniProtKB
Regulation of liquid surface tension Source: UniProtKB
Regulation of sodium ion transmembrane transport Source: UniProtKB
Cellular Location
Secreted. Apical side of airway epithelial cells. Detected in airway surface liquid, nasal mucus and sputum.
PTM
May be N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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