Mouse Anti-SPR Recombinant Antibody (CBXS-4848) (CBMAB-S2072-CQ)

Name: Mouse Anti-SPR Recombinant Antibody (CBXS-4848)
SKU: CBMAB-S2072-CQ
Rating: 5 (1 reviews)

See all SPR antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXS-4848

Application

FC, IF, WB

Immunogen

Recombinant full length human SPR (NP_003115)

Specificity

Human, Monkey

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Sepiapterin Reductase

Introduction

This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1.

Entrez Gene ID

Human	6697
Monkey	705317

UniProt ID

Human	P35270
Monkey	F6YUE9

Alternative Names

Sepiapterin Reductase; Sepiapterin Reductase (7,8-Dihydrobiopterin:NADP+ Oxidoreductase); Sepiapterin Reductase (L-Erythro-7,8-Dihydrobiopterin Forming); Short Chain Dehydrogenase/Reductase Family 38C, Member 1; EC 1.1.1.153; SDR38C1;

Function

Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.

Biological Process

Biological Process nitric oxide biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process tetrahydrobiopterin biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm

Involvement in disease

Dystonia, DOPA-responsive, due to sepiapterin reductase deficiency (DRDSPRD):
A form of DOPA-responsive dystonia. In the majority of cases, patients manifest progressive psychomotor retardation, dystonia and spasticity. Cognitive anomalies are also often present. The disease is due to severe dopamine and serotonin deficiencies in the central nervous system caused by a defect in BH4 synthesis. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures.

PTM

In vitro phosphorylation of Ser-213 by CaMK2 does not change kinetic parameters.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-SPR Recombinant Antibody (CBXS-4848)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

SPR Matched Antibody Pair (1140) (CAT#: APMAB-1140LY)

SPR Matched Antibody Pair (1141) (CAT#: APMAB-1141LY)

Related Products

SPR Matched Antibody Pair (1141) (CAT#: APMAB-1141LY)

Mouse Anti-SPR Recombinant Antibody (CBXS-4861) (CAT#: CBMAB-S2084-CQ)

Rabbit Anti-SPR Recombinant Antibody (CBXS-1635) (CAT#: CBMAB-S4484-CQ)

Mouse Anti-SPR Recombinant Antibody (CBXS-4453) (CAT#: CBMAB-S1695-CQ)

Mouse Anti-SPR Recombinant Antibody (CBXS-4819) (CAT#: CBMAB-S2044-CQ)

Rabbit Anti-SPR Recombinant Antibody (CBXS-1636) (CAT#: CBMAB-S4485-CQ)

Mouse Anti-SPR Recombinant Antibody (4F2) (CAT#: CBMAB-A8567-LY)

Mouse Anti-SPR Recombinant Antibody (CBXS-4118) (CAT#: CBMAB-S1373-CQ)

Mouse Anti-SPR Recombinant Antibody (CBXS-2009) (CAT#: CBMAB-S4776-CQ)

Mouse Anti-SPR Recombinant Antibody (CBXS-4753) (CAT#: CBMAB-S1982-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry