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Mouse Anti-SPSB4 Recombinant Antibody (CBXS-2113) (CBMAB-S4878-CQ)

This product is a mouse antibody that recognizes SPSB4. The antibody CBXS-2113 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all SPSB4 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBXS-2113
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SplA/Ryanodine Receptor Domain And SOCS Box Containing 4
Introduction
SPSB4 (SplA/Ryanodine Receptor Domain And SOCS Box Containing 4) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is SPSB1.
Entrez Gene ID
Human92369
Mouse211949
Rat300950
UniProt ID
HumanQ96A44
MouseQ8R5B6
RatB5DF38
Alternative Names
SplA/Ryanodine Receptor Domain And SOCS Box Containing 4; SSB-4; SSB4; SPRY Domain-Containing SOCS Box Protein SSB-4; SPRY Domain-Containing SOCS Box Protein 4;
Function
Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21199876, PubMed:15601820).
Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876).
Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876).
Diminishes EphB2-dependent cell repulsive responses by mediating the ubiquitination and degradation of EphB2/CTF2 (PubMed:28931592).
Regulates cellular clock function by mediating the ubiquitin/proteasome-dependent degradation of the circadian transcriptional repressor NR1D1 (PubMed:26392558).
Biological Process
Biological Process intracellular signal transductionIEA:InterPro
Biological Process positive regulation of protein polyubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of circadian rhythmManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process rhythmic processIEA:UniProtKB-KW
Biological Process ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Cytoplasm, cytosol
Exhibits a diffuse cytosolic localization.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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