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Mouse Anti-SPTB Recombinant Antibody (CBXS-5002) (CBMAB-S2224-CQ)

This product is a mouse antibody that recognizes SPTB. The antibody CBXS-5002 can be used for immunoassay techniques such as: FC, IF, IHC, IHC-P, WB.
See all SPTB antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBXS-5002
Antibody Isotype
IgG1
Application
FC, IF, IHC, IHC-P, WB

Basic Information

Immunogen
Purified human erythrocyte beta-1 spectrin
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Ascites fluid
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Spectrin Beta, Erythrocytic
Introduction
This locus encodes a member of the spectrin gene family. Spectrin proteins, along with ankyrin, play a role in cell membrane organization and stability. The protein encoded by this locus functions in stability of erythrocyte membranes, and mutations in this gene have been associated with spherocytosis type 2, hereditary elliptocytosis, and neonatal hemolytic anemia. Alternatively spliced transcript variants have been described.
Entrez Gene ID
Human6710
Mouse20741
Rat314251
UniProt ID
HumanP11277
MouseP15508
RatQ6XDA0
Alternative Names
Spectrin Beta, Erythrocytic; Beta-I Spectrin; Spectrin Beta Chain, Erythrocytic; Spectrin Beta Chain, Erythrocyte; Spherocytosis, Clinical Type I; Membrane Cytoskeletal Protein; Spectrin Beta Tandil;
Function
Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
Biological Process
Biological Process actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process actin filament cappingIEA:UniProtKB-KW
Cellular Location
Cytoplasm, cytoskeleton
Cytoplasm, cell cortex
Involvement in disease
Elliptocytosis 3 (EL3):
A Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous hematologic disorder characterized by variable hemolytic anemia and elliptical or oval red cell shape. Inheritance can be autosomal dominant or autosomal recessive.
Spherocytosis 2 (SPH2):
An autosomal dominant form of hereditary spherocytosis, a group of hematologic disorders characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Clinical manifestations include chronic hemolytic anemia, jaundice, and splenomegaly, with variable severity.
PTM
The first phosphorylation event occurs on Ser-2114, followed by Ser-2125, Ser-2123, Ser-2128, Ser-2117, and Thr-2110.
(Microbial infection) Probably cleaved by P.falciparum SERA6; the cleavage results in SPTB solubilization causing the disruption of the actin cytoskeleton and the rupture of the erythrocyte cell membrane releasing the merozoites.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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