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Mouse Anti-SPTLC2 Recombinant Antibody (CBXS-2249) (CBMAB-S5011-CQ)

This product is a mouse antibody that recognizes SPTLC2. The antibody CBXS-2249 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all SPTLC2 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBXS-2249
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Serine Palmitoyltransferase Long Chain Base Subunit 2
Introduction
This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I.
Entrez Gene ID
Human9517
Mouse20773
Rat366697
UniProt ID
HumanO15270
MouseP97363
RatQ3B7D2
Alternative Names
Serine Palmitoyltransferase Long Chain Base Subunit 2; Long Chain Base Biosynthesis Protein 2a; Serine-Palmitoyl-CoA Transferase 2; EC 2.3.1.50; LCB 2; SPT 2; LCB2A; LCB2; Serine Palmitoyltransferase, Subunit II;
Function
Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate. Plays an important role in de novo sphyngolipid biosynthesis which is crucial for adipogenesis (By similarity).
Biological Process
Biological Process adipose tissue developmentISS:UniProtKB
Biological Process ceramide biosynthetic processManual Assertion Based On ExperimentIDA:MGI
Biological Process positive regulation of lipophagyManual Assertion Based On ExperimentIDA:MGI
Biological Process sphinganine biosynthetic processIEA:Ensembl
Biological Process sphingolipid biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process sphingomyelin biosynthetic processIEA:Ensembl
Biological Process sphingosine biosynthetic processManual Assertion Based On ExperimentIDA:ComplexPortal
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
Neuropathy, hereditary sensory and autonomic, 1C (HSAN1C):
A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by prominent sensory abnormalities with a variable degree of motor and autonomic dysfunction. The neurological phenotype is often complicated by severe infections, osteomyelitis, and amputations. HSAN1C symptoms include loss of touch and vibration in the feet, dysesthesia and severe panmodal sensory loss in the upper and lower limbs, distal lower limb sensory loss with ulceration and osteomyelitis, and distal muscle weakness.
Topology
Helical: 67-87
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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