Rabbit Anti-SRC1 Recombinant Antibody (128E7) (CBMAB-CP2574-LY)

Name: Rabbit Anti-SRC1 Recombinant Antibody (128E7)
SKU: CBMAB-CP2574-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

128E7

Application

WB, IP, IHC-P, CIP

Immunogen

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the sequence of human SRC-1 protein.

Specificity

Human, Mouse, Rat, Monkey

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

100 µg/ml BSA, 50% glycerol

Preservative

0.02% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

NCOA1

Entrez Gene ID

Human	8648
Mouse	17977
Rat	313929
Monkey	718524

UniProt ID

Human	Q15788
Mouse	P70365
Rat	D4A3Q3
Monkey	H9G174

Function

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.

Biological Process

Cellular response to hormone stimulus Source: GO_Central
Cellular response to Thyroglobulin triiodothyronine Source: Ensembl
Histone H4 acetylation Source: Ensembl
Labyrinthine layer morphogenesis Source: Ensembl
mRNA transcription by RNA polymerase II Source: ComplexPortal
Peroxisome proliferator activated receptor signaling pathway Source: ComplexPortal
Positive regulation of adipose tissue development Source: ComplexPortal
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of neuron differentiation Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of transcription from RNA polymerase II promoter by galactose Source: UniProtKB
Regulation of cellular response to insulin stimulus Source: ComplexPortal
Regulation of thyroid hormone mediated signaling pathway Source: Ensembl

Involvement in disease

A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children.

PTM

Sumoylated; sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not prevent its ubiquitination and does not exert a clear effect on the stability of the protein.
Ubiquitinated; leading to proteasome-mediated degradation. Ubiquitination and sumoylation take place at different sites.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Rabbit Anti-SRC1 Recombinant Antibody (D1M3Y) (CAT#: CBMAB-CP2573-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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