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NCOA1

The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified.
Full Name
NCOA1
Function
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.
Biological Process
Cellular response to hormone stimulus Source: GO_Central
Cellular response to Thyroglobulin triiodothyronine Source: Ensembl
Histone H4 acetylation Source: Ensembl
Labyrinthine layer morphogenesis Source: Ensembl
mRNA transcription by RNA polymerase II Source: ComplexPortal
Peroxisome proliferator activated receptor signaling pathway Source: ComplexPortal
Positive regulation of adipose tissue development Source: ComplexPortal
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of neuron differentiation Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of transcription from RNA polymerase II promoter by galactose Source: UniProtKB
Regulation of cellular response to insulin stimulus Source: ComplexPortal
Regulation of thyroid hormone mediated signaling pathway Source: Ensembl
Involvement in disease
A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children.
PTM
Sumoylated; sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not prevent its ubiquitination and does not exert a clear effect on the stability of the protein.
Ubiquitinated; leading to proteasome-mediated degradation. Ubiquitination and sumoylation take place at different sites.

Anti-NCOA1 antibodies

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Target: NCOA1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1E8
Application*: IP, M
Target: NCOA1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1B11
Application*: IP, WB, M
Target: NCOA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: SRC01
Application*: IF, P, WB
Target: NCOA1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-3454
Application*: DB, WB
Target: NCOA1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Monkey, Mouse, Rat
Clone: CBXS-2307
Application*: IH, IP, WB
Target: NCOA1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBXS-0048
Application*: WB, CI
Target: NCOA1
Host: Rabbit
Specificity: Human, Mouse, Rat, Monkey
Clone: CBXS-3681
Application*: WB, IP, P, CI
Target: NCOA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Monkey
Clone: CBXS-3640
Application*: WB, CI, IP, IF
Target: NCOA1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJN-0773
Application*: IP, WB
Target: NCOA1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human, Mouse
Clone: 9A6
Application*: IA, F, IF, WB
Target: NCOA1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5D10C4
Application*: WB
Target: NCOA1
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: 5A18
Application*: P, WB
Target: NCOA1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4F1E8
Application*: IA, WB
Target: NCOA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1F11
Application*: IA, F, P, WB
Target: NCOA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 17AT28
Application*: IA, P, IP, WB
Target: NCOA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog, Human, Mouse, Rat
Clone: 11F1
Application*: IA, WB
Target: NCOA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Mouse, Rat
Clone: CBWJN-1219
Application*: WB, IH, IP
Target: NCOA1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJN-0955
Application*: IP, WB
Target: NCOA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Human, Monkey
Clone: 1135/H4
Application*: WB, IP, P, F, CI
Target: NCOA1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3532C6a
Application*: WB, DB
Target: NCOA1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLY1-169
Application*: WB, IP, P
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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