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Rabbit Anti-SRGAP2 Recombinant Antibody (CBXS-1192) (CBMAB-S4058-CQ)

This product is a rabbit antibody that recognizes SRGAP2. The antibody CBXS-1192 can be used for immunoassay techniques such as: WB.
See all SRGAP2 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBXS-1192
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SLIT-ROBO Rho GTPase Activating Protein 2
Introduction
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus.
Entrez Gene ID
Human23380
Mouse14270
Rat360840
UniProt ID
HumanO75044
MouseQ91Z67
RatD4A208
Alternative Names
SLIT-ROBO Rho GTPase Activating Protein 2; Rho GTPase-Activating Protein 34; Formin-Binding Protein 2; ARHGAP34; SRGAP2A; FNBP2; SLIT-ROBO Rho GTPase-Activating Protein 2;
Function
Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:20810653, PubMed:27373832, PubMed:28333212).
Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832).
SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (By similarity).
Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:27373832).
Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (By similarity).
In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:20810653, PubMed:21148482).
Biological Process
Biological Process actin filament severingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process dendritic spine developmentManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process excitatory synapse assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process extension of a leading process involved in cell motility in cerebral cortex radial glia guided migrationISS:UniProtKB
Biological Process filopodium assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process inhibitory synapse assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process lamellipodium assembly involved in ameboidal cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of neuron migrationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process neuron projection morphogenesisISS:UniProtKB
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of small GTPase mediated signal transductionTAS:Reactome
Biological Process signal transductionIEA:InterPro
Biological Process substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Cell projection, dendritic spine
Postsynaptic density
Postsynaptic cell membrane
Cell projection, lamellipodium
Cytoplasmic vesicle, phagosome
Nucleus
Cytoplasm, cytosol
Recruited to actin-rich phagosomes during phagocytosis (By similarity).
Translocates from nucleus to cytoplasm during development (By similarity).
Involvement in disease
A chromosomal aberration disrupting SRGAP2 has been found in a patient with early infantile epileptic encephalopathy. Balanced translocation t(1;9)(q32;q13) (PubMed:22106086).
PTM
Methylation at Arg-927 is required for the stimulation of cell migration, dimerization and localization at the plasma membrane protrusions.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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