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Rabbit Anti-SRP72 Recombinant Antibody (CBXS-1433) (CBMAB-S4291-CQ)

This product is a rabbit antibody that recognizes SRP72. The antibody CBXS-1433 can be used for immunoassay techniques such as: WB, FC, IF.
See all SRP72 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXS-1433
Antibody Isotype
IgG
Application
WB, FC, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Signal Recognition Particle 72
Introduction
This gene encodes the 72 kDa subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the targeting of secretory proteins to the endoplasmic reticulum (ER). The SRP complex consists of a 7S RNA and 6 protein subunits: SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72, that are bound to the 7S RNA as monomers or heterodimers. SRP has at least 3 distinct functions that can be associated with the protein subunits: signal recognition, translational arrest, and ER membrane targeting by interaction with the docking protein. Mutations in this gene are associated with familial bone marrow failure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
6731
UniProt ID
O76094
Alternative Names
Signal Recognition Particle 72; Signal Recognition Particle 72 KDa Protein; Signal Recognition Particle 72kDa; Signal Recognition Particle Subunit SRP72; Signal Recognition Particle 72kD; Epididymis Luminal Protein 103; HEL103; BMFS1; BMFF;
Function
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957).
The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:34020957).
The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (PubMed:34020957).
Binds the signal recognition particle RNA (7SL RNA) in presence of SRP68 (PubMed:27899666, PubMed:21073748).
Can bind 7SL RNA with low affinity (PubMed:27899666, PubMed:21073748).
The SRP complex possibly participates in the elongation arrest function (By similarity).
Biological Process
SRP-dependent cotranslational protein targeting to membrane
Cellular Location
Cytoplasm
Endoplasmic reticulum
Involvement in disease
Bone marrow failure syndrome 1 (BMFS1):
An autosomal dominant disease characterized by aplastic anemia and myelodysplasia resulting from bone marrow failure. Aplastic anemia is a form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. Myelodysplasia is a clonal hematopoietic stem cell disorder in which immature cells in the bone marrow become malformed and dysfunctional.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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