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Mouse Anti-SRPX2 Recombinant Antibody (CBXS-4342) (CBMAB-S1587-CQ)

This product is a mouse antibody that recognizes SRPX2. The antibody CBXS-4342 can be used for immunoassay techniques such as: ELISA, WB, IHC, IF.
See all SRPX2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Pig
Clone
CBXS-4342
Antibody Isotype
IgG2b
Application
ELISA, WB, IHC, IF

Basic Information

Specificity
Human, Mouse, Pig
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sushi Repeat Containing Protein, X-Linked 2
Introduction
This gene encodes a secreted protein that contains three sushi repeat motifs. The encoded protein may play a role in the development of speech and language centers in the brain. This protein may also be involved in angiogenesis. Mutations in this gene are the cause of bilateral perisylvian polymicrogyria, rolandic epilepsy, speech dyspraxia and cognitive disability.
Entrez Gene ID
Human27286
Mouse68792
Pig100153130
UniProt ID
HumanO60687
MouseQ8R054
PigF1S1M3
Alternative Names
Sushi Repeat Containing Protein, X-Linked 2; Sushi-Repeat Protein Upregulated In Leukemia; SRPUL; Sushi-Repeat Protein Up-Regulated In Leukemia; Sushi-Repeat-Containing Protein, X-Linked 2; Sushi Repeat-Containing Protein SRPX2;
Function
Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive development.
Biological Process
Biological Process angiogenesisIEA:UniProtKB-KW
Biological Process cell motilityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cell-cell adhesionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of cell migration involved in sprouting angiogenesisISS:UniProtKB
Biological Process positive regulation of synapse assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process vocalization behaviorIEA:Ensembl
Cellular Location
Secreted
Cytoplasm
Cell surface
Synapse
Involvement in disease
Rolandic epilepsy, impaired intellectual development, and speech dyspraxia, X-linked (RESDX):
A condition characterized by the association of rolandic seizures with oral and speech dyspraxia, and intellectual disability. Rolandic seizures occur during a period of significant brain maturation. During this time, dysfunction of neural network activities such as focal discharges may be associated with specific developmental disabilities resulting in specific cognitive impairments of language, visuo-spatial abilities or attention.
PTM
Contains chondroitin sulfate chains.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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