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Mouse Anti-SRSF6 Recombinant Antibody (CBXS-5182) (CBMAB-S2400-CQ)

This product is a mouse antibody that recognizes SRSF6. The antibody CBXS-5182 can be used for immunoassay techniques such as: ELISA, WB.
See all SRSF6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-5182
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Serine And Arginine Rich Splicing Factor 6
Introduction
The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants. In addition, two pseudogenes, one on chromosome 17 and the other on the X chromosome, have been found for this gene.
Entrez Gene ID
UniProt ID
Alternative Names
Serine And Arginine Rich Splicing Factor 6; Splicing Factor, Arginine/Serine-Rich 6; Serine/Arginine-Rich Splicing Factor 6; Pre-MRNA-Splicing Factor SRP55; SR Splicing Factor 6; SFRS6; SRP55;
Function
Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing.
Biological Process
Biological Process alternative mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process mRNA splice site selectionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of cell deathManual Assertion Based On ExperimentIDA:MGI
Biological Process negative regulation of keratinocyte differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of type B pancreatic cell apoptotic processIEA:Ensembl
Biological Process positive regulation of epithelial cell proliferation involved in lung morphogenesisManual Assertion Based On ExperimentIDA:MGI
Biological Process regulation of alternative mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:MGI
Biological Process regulation of keratinocyte proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of wound healingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process response to insulinIEA:Ensembl
Cellular Location
Nucleus
Nucleus speckle
PTM
Extensively phosphorylated on serine residues in the RS domain. Phosphorylated by DYRK1A, probably in the RS domain. Phosphorylation by DYRK1A modulates alternative splice site selection and inhibits the expression of MAPT/Tau exon 10.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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