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Mouse Anti-SS18L1 Recombinant Antibody (CBXS-5597) (CBMAB-S0475-CQ)

This product is a mouse antibody that recognizes SS18L1. The antibody CBXS-5597 can be used for immunoassay techniques such as: ELISA, WB.
See all SS18L1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBXS-5597
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SS18L1, NBAF Chromatin Remodeling Complex Subunit
Introduction
This gene encodes a calcium-responsive transactivator which is an essential subunit of a neuron-specific chromatin-remodeling complex. The structure of this gene is similar to that of the SS18 gene. Mutations in this gene are involved in amyotrophic lateral sclerosis (ALS). Alternatively spliced transcript variants have been found for this gene.
Entrez Gene ID
Human26039
Mouse269397
Rat192352
UniProt ID
HumanO75177
MouseQ8BW22
RatQ91XJ0
Alternative Names
SS18L1, NBAF Chromatin Remodeling Complex Subunit; Synovial Sarcoma Translocation Gene On Chromosome 18-Like 1; Calcium-Responsive Transactivator; SS18-Like Protein 1; SYT Homolog 1; CREST; KIAA0693; LP2261;
Function
Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity).
Biological Process
Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process dendrite developmentIEA:Ensembl
Biological Process positive regulation of dendrite morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of DNA-templated transcriptionISS:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Chromosome, centromere, kinetochore
Localizes to nuclear bodies. Colocalizes with SGO1 at kinetochore (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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