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Mouse Anti-SSH3 Recombinant Antibody (6F9) (CBMAB-S2885-CQ)

This product is a mouse antibody that recognizes SSH3. The antibody 6F9 can be used for immunoassay techniques such as: WB, IHC-P, IF.
See all SSH3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6F9
Antibody Isotype
IgG2a
Application
WB, IHC-P, IF

Basic Information

Immunogen
Recombinant protein corresponding to aa 293-392 of human SSH3
Specificity
Human
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
slingshot homolog 3 (Drosophila)
Introduction
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).
Entrez Gene ID
54961
UniProt ID
Q8TE77
Alternative Names
Slingshot Protein Phosphatase 3; SSH-Like Protein 3; HSSH-3L; SSH-3L; SSH3L; Protein Phosphatase Slingshot Homolog 3;
Function
Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly (By similarity).
Biological Process
Biological Process actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of actin filament polymerizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein dephosphorylationIEA:InterPro
Cellular Location
Cytoplasm, cytoskeleton
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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