Rabbit Anti-ST3GAL3 Recombinant Antibody (CBXS-1455) (CBMAB-S4312-CQ)

Name: Rabbit Anti-ST3GAL3 Recombinant Antibody (CBXS-1455)
SKU: CBMAB-S4312-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

CBXS-1455

Application

WB, IHC-P, FC, IF

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

ST3 beta-galactoside alpha-2,3-sialyltransferase 3

Introduction

The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Mutations in this gene have been associated with autosomal recessive nonsymdromic mental retardation-12 (MRT12). Multiple transcript variants encoding several different isoforms have been found for this gene.

Entrez Gene ID

Human	6487
Mouse	20441
Rat	64445

UniProt ID

Human	Q11203
Mouse	P97325
Rat	Q02734

Alternative Names

ST3N; MRT12; SIAT6; EIEE15; ST3GALII; ST3GalIII

Function

Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- and NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc.

Biological Process

Biological Process ganglioside biosynthetic process via lactosylceramideIEA:Ensembl
Biological Process keratan sulfate biosynthetic processTAS:Reactome
Biological Process O-glycan processingTAS:Reactome
Biological Process oligosaccharide biosynthetic processTAS:Reactome
Biological Process protein glycosylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process viral protein processingTAS:Reactome

Cellular Location

Golgi apparatus, Golgi stack membrane
Secreted
Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.

Involvement in disease

Intellectual developmental disorder, autosomal recessive 12 (MRT12):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Developmental and epileptic encephalopathy 15 (DEE15):
A form of epilepsy that manifests in the neonatal or the early infantile period as severely impaired cognitive and motor development, due to recurrent clinical seizures or prominent interictal epileptiform discharges. Patients develop infantile spasms, mainly of the flexor type, between 3 and 7 months of age, which are accompanied by hypsarrhythmia on EEG. Other features include poor eye contact, hypotonia, primitive reflexes, and irritability. Seizures evolve clinically to Lennox-Gastaut syndrome.

Topology

Cytoplasmic: 1-8
Helical: 9-28
Lumenal: 29-375

PTM

The soluble form derives from the membrane form by proteolytic processing.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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