Sign in or Register   Sign in or Register
  |  

Rabbit Anti-ST3GAL3 Recombinant Antibody (CBXS-1455) (CBMAB-S4312-CQ)

This product is a rabbit antibody that recognizes ST3GAL3. The antibody CBXS-1455 can be used for immunoassay techniques such as: WB, IHC-P, FC, IF.
See all ST3GAL3 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBXS-1455
Antibody Isotype
IgG
Application
WB, IHC-P, FC, IF

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
Introduction
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Mutations in this gene have been associated with autosomal recessive nonsymdromic mental retardation-12 (MRT12). Multiple transcript variants encoding several different isoforms have been found for this gene.
Entrez Gene ID
Human6487
Mouse20441
Rat64445
UniProt ID
HumanQ11203
MouseP97325
RatQ02734
Alternative Names
ST3N; MRT12; SIAT6; EIEE15; ST3GALII; ST3GalIII
Function
Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- and NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc.
Biological Process
Biological Process ganglioside biosynthetic process via lactosylceramideIEA:Ensembl
Biological Process keratan sulfate biosynthetic processTAS:Reactome
Biological Process O-glycan processingTAS:Reactome
Biological Process oligosaccharide biosynthetic processTAS:Reactome
Biological Process protein glycosylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process viral protein processingTAS:Reactome
Cellular Location
Golgi apparatus, Golgi stack membrane
Secreted
Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
Involvement in disease
Intellectual developmental disorder, autosomal recessive 12 (MRT12):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Developmental and epileptic encephalopathy 15 (DEE15):
A form of epilepsy that manifests in the neonatal or the early infantile period as severely impaired cognitive and motor development, due to recurrent clinical seizures or prominent interictal epileptiform discharges. Patients develop infantile spasms, mainly of the flexor type, between 3 and 7 months of age, which are accompanied by hypsarrhythmia on EEG. Other features include poor eye contact, hypotonia, primitive reflexes, and irritability. Seizures evolve clinically to Lennox-Gastaut syndrome.
Topology
Cytoplasmic: 1-8
Helical: 9-28
Lumenal: 29-375
PTM
The soluble form derives from the membrane form by proteolytic processing.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-ST3GAL3 Recombinant Antibody (CBXS-1455)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare