Mouse Anti-ST3GAL4 Recombinant Antibody (CBXS-4122) (CBMAB-S1376-CQ)

ST3 beta-galactoside alpha-2,3-sialyltransferase 4

This gene encodes a member of the glycosyltransferase 29 family, a group of enzymes involved in protein glycosylation. The encoded protein is targeted to Golgi membranes but may be proteolytically processed and secreted. The gene product may also be involved in the increased expression of sialyl Lewis X antigen seen in inflammatory responses. Multiple transcript variants encoding different isoforms have been found for this gene.

CGS23; NANTA3; SAT3; SIAT4; SIAT4C; ST-4; ST3GalA.2; ST3GalIV; STZ; gal-NAc6S

A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:8288606, PubMed:8611500).
Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc- and Galbeta-(1->4)-GlcNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:8288606, PubMed:8611500).
Plays a major role in hemostasis. Responsible for sialylation of plasma VWF/von Willebrand factor, preventing its recognition by asialoglycoprotein receptors (ASGPR) and subsequent clearance. Regulates ASGPR-mediated clearance of platelets (By similarity).
Participates in the biosynthesis of the sialyl Lewis X epitopes, both on O- and N-glycans, which are recognized by SELE/E-selectin, SELP/P-selectin and SELL/L-selectin. Essential for selectin-mediated rolling and adhesion of leukocytes during extravasation (PubMed:25498912).
Contributes to adhesion and transendothelial migration of neutrophils likely through terminal sialylation of CXCR2 (By similarity).
In glycosphingolipid biosynthesis, sialylates GM1 and GA1 gangliosides to form GD1a and GM1b, respectively (PubMed:8288606).
Metabolizes brain c-series ganglioside GT1c forming GQ1c (By similarity).
Synthesizes ganglioside LM1 (IV3Neu5Ac-nLc4Cer), a major structural component of peripheral nerve myelin (PubMed:8611500).

Biological Process cognitionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process glycolipid biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process glycoprotein biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process keratan sulfate biosynthetic processTAS:Reactome
Biological Process lipid glycosylationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process O-glycan processingTAS:Reactome
Biological Process oligosaccharide biosynthetic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of blood coagulationISS:UniProtKB
Biological Process positive regulation of leukocyte tethering or rollingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein glycosylationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process protein sialylationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process sialylationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process viral protein processingTAS:Reactome

Golgi apparatus, Golgi stack membrane
Secreted
Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.

Cytoplasmic: 1-8
Helical: 9-26
Lumenal: 27-333

The soluble form derives from the membrane form by proteolytic processing.