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Mouse Anti-ST5 Recombinant Antibody (CBXS-2669) (CBMAB-S5421-CQ)

This product is a mouse antibody that recognizes ST5. The antibody CBXS-2669 can be used for immunoassay techniques such as: ELISA.
See all ST5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2669
Antibody Isotype
IgG1, κ
Application
ELISA

Basic Information

Immunogen
Partial recombinant corresponding to aa1038-1136 from human ST5 (NP_005409) with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
suppression of tumorigenicity 5
Introduction
This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified.
Entrez Gene ID
6764
UniProt ID
P78524
Alternative Names
DENND2B; HTS1; p126
Function
Isoform 1
May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane (PubMed:29030480).
Isoform 2
Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
Isoform 3
May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable).
Biological Process
Positive regulation of ERK1 and ERK2 cascade
Cellular Location
Isoform 1
Cytoplasm, cell cortex
Cell membrane
Recycling endosome
Colocalizes with RAB13 and ITSN1 at cytoplasmic vesicles that are most likely recycling endosomes. Colocalizes with the cortical actin cytoskeleton.
PTM
Phosphorylated. Phosphorylation decreases ITSN1 binding.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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