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Mouse Anti-ST6GALNAC6 Recombinant Antibody (CF409) (CBMAB-FT111LY)

The product is antibody recognizes ST6GALNAC6 . The antibody CF409 immunoassay techniques such as: ELISA, WB, IHC.
See all ST6GALNAC6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CF409
Antibody Isotype
IgG2a
Application
ELISA, WB, IHC

Basic Information

Immunogen
ST6 (alpha-N-acetyl-neuraminyl-2, 3-beta-galactosyl-1, 3) -N-acetylgalactosaminide alpha-2, 6-sialyltransferase 6
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 6
Entrez Gene ID
30815
UniProt ID
Q969X2
Alternative Names
SIAT7F
Function
Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycoproteins and glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3-linkage on Gal. ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:12668675, PubMed:17123352).
Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (PubMed:12668675).
Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) (By similarity).
Biological Process
Biological Process cell-cell recognition1 PublicationIC:BHF-UCL
Biological Process ganglioside biosynthetic processISS:BHF-UCL
Biological Process glycoprotein metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process glycosphingolipid metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process glycosylceramide metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process oligosaccharide biosynthetic processBy SimilarityISS:BHF-UCL
Biological Process oligosaccharide metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein glycosylationIEA:InterPro
Cellular Location
Golgi apparatus membrane
Topology
Cytoplasmic: 1-43
Helical: 44-64
Lumenal: 65-333
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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