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Mouse Anti-STAB1 Recombinant Antibody (FE-1-2) (CBMAB-S6327-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
FE-1-2
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2, 50% glycerol
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
stabilin 1
Introduction
This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes.
Entrez Gene ID
23166
UniProt ID
Q9NY15
Alternative Names
STAB1; stabilin 1; FEX1; FEEL-1; FELE-1; STAB-1; CLEVER-1; stabilin-1; MS-1 antigen; common lymphatic endothelial and vascular endothelial receptor-1; fasciclin egf-like; laminin-type egf-like; and link domain-containing scavenger receptor-1; fasciclin; EGF-like; laminin-type EGF-like and link domain-containing scavenger receptor 1; FP-1302; Clevergen
Function
Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system.
Biological Process
Biological Process cell adhesion1 PublicationNAS:UniProtKB
Biological Process cell-cell signalingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process inflammatory responseIEA:UniProtKB-KW
Biological Process negative regulation of angiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process receptor-mediated endocytosisManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Membrane
Topology
Extracellular: 26-2478
Helical: 2479-2499
Cytoplasmic: 2500-2570
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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