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Mouse Anti-STAG1 Recombinant Antibody (CBXS-5912) (CBMAB-S0761-CQ)

This product is a mouse antibody that recognizes STAG1. The antibody CBXS-5912 can be used for immunoassay techniques such as: WB, IF, IP.
See all STAG1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-5912
Antibody Isotype
IgG2a
Application
WB, IF, IP

Basic Information

Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human SA1
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
stromal antigen 1
Introduction
This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase.
Entrez Gene ID
10274
UniProt ID
Q8WVM7
Alternative Names
MRD47; SA1; SCC3A
Function
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
Biological Process
Biological Process cell divisionIEA:UniProtKB-KW
Biological Process establishment of meiotic sister chromatid cohesion1 PublicationIC:ComplexPortal
Biological Process localizationManual Assertion Based On ExperimentIDA:DisProt
Biological Process mitotic spindle assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process sister chromatid cohesionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Chromosome
Chromosome, centromere
Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation.
Involvement in disease
Intellectual developmental disorder, autosomal dominant 47 (MRD47):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD47 patients manifest developmental delay and mild to moderate intellectual disability, usually with delayed speech.
PTM
Phosphorylated by PLK1. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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