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Mouse Anti-STARD3 Recombinant Antibody (CBXS-2729) (CBMAB-S5480-CQ)

This product is a mouse antibody that recognizes STARD3. The antibody CBXS-2729 can be used for immunoassay techniques such as: ELISA, WB.
See all STARD3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2729
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa1-445 from human STARD3 (AAH08747) with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
StAR-related lipid transfer (START) domain containing 3
Introduction
This gene encodes a member of a subfamily of lipid trafficking proteins that are characterized by a C-terminal steroidogenic acute regulatory domain and an N-terminal metastatic lymph node 64 domain. The encoded protein localizes to the membranes of late endosomes and may be involved in exporting cholesterol. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
10948
UniProt ID
Q14849
Alternative Names
CAB1; MLN64; es64
Function
Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:11053434, PubMed:15930133, PubMed:22514632, PubMed:28377464).
Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263, PubMed:28377464).
Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (PubMed:28377464).
May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane (PubMed:12070139, PubMed:19965586).
However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:28377464).
Does not activate transcriptional cholesterol sensing (PubMed:28377464).
Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina (PubMed:21322544).
Biological Process
Biological Process cholesterol metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process cholesterol transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process lipid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process mitochondrial transportManual Assertion Based On ExperimentTAS:ProtInc
Biological Process progesterone biosynthetic processIEA:Ensembl
Biological Process steroid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process vesicle tethering to endoplasmic reticulumManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Late endosome membrane
Localizes to contact sites between the endoplasmic reticulum and late endosomes: associates with the endoplasmic reticulum membrane via interaction with VAPA, VAPB or MOSPD2.
Topology
Cytoplasmic: 1-51
Helical: 52-72
Extracellular: 73-94
Helical: 95-115
Cytoplasmic: 116-120
Helical: 121-141
Extracellular: 142-148
Helical: 149-169
Cytoplasmic: 170-445
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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