Mouse Anti-STC1 Recombinant Antibody (CBXS-3806) (CBMAB-S1077-CQ)

stanniocalcin 1

This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers.

STC

Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.

Biological Process bone developmentManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular calcium ion homeostasisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to cAMPIEA:Ensembl
Biological Process cellular response to glucocorticoid stimulusIEA:Ensembl
Biological Process cellular response to hypoxiaIEA:Ensembl
Biological Process chondrocyte proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process decidualizationIEA:Ensembl
Biological Process embryo implantationIEA:Ensembl
Biological Process endothelial cell morphogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process growth plate cartilage axis specificationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of calcium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of endothelial cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of renal phosphate excretionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process ossificationIEA:Ensembl
Biological Process positive regulation of calcium ion importManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of anion transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of cardiac muscle cell contractionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to vitamin DIEA:Ensembl

Secreted