STC1

This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq]

Full Name

stanniocalcin 1

Function

Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.

Biological Process

Biological Process bone developmentManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular calcium ion homeostasisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to cAMPIEA:Ensembl
Biological Process cellular response to glucocorticoid stimulusIEA:Ensembl
Biological Process cellular response to hypoxiaIEA:Ensembl
Biological Process chondrocyte proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process decidualizationIEA:Ensembl
Biological Process embryo implantationIEA:Ensembl
Biological Process endothelial cell morphogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process growth plate cartilage axis specificationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of calcium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of endothelial cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of renal phosphate excretionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process ossificationIEA:Ensembl
Biological Process positive regulation of calcium ion importManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of anion transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of cardiac muscle cell contractionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to vitamin DIEA:Ensembl

Cellular Location

Secreted