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Rabbit Anti-STEAP3 Recombinant Antibody (CBXS-1648) (CBMAB-S4497-CQ)

This product is a rabbit antibody that recognizes STEAP3. The antibody CBXS-1648 can be used for immunoassay techniques such as: WB, IF.
See all STEAP3 antibodies

Summary

Host Animal
Rabbit
Specificity
Rat, Human
Clone
CBXS-1648
Antibody Isotype
IgG
Application
WB, IF

Basic Information

Specificity
Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
STEAP3 Metalloreductase
Introduction
This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human55240
Rat170824
UniProt ID
HumanQ658P3
RatQ5RKL5
Alternative Names
AHMIO2; STMP3; TSAP6; dudlin-2; dudulin-2; pHyde
Function
Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe3+ to Fe2+. Can also reduce of Cu2+ to Cu1+, suggesting that it participates in copper homeostasis. Uses NADP+ as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.
Biological Process
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process cell cycleIEA:UniProtKB-KW
Biological Process copper ion importManual Assertion Based On ExperimentIBA:GO_Central
Biological Process iron ion homeostasisIEA:UniProtKB-KW
Biological Process protein secretionManual Assertion Based On ExperimentIDA:MGI
Biological Process transferrin transportTAS:Reactome
Cellular Location
Endosome membrane
Localizes to vesicular-like structures at the plasma membrane and around the nucleus.
Involvement in disease
Anemia, hypochromic microcytic, with iron overload 2 (AHMIO2):
A hematologic disease characterized by abnormal hemoglobin content in the erythrocytes which are reduced in size, severe anemia, erythropoietic hyperplasia of bone marrow, massive hepatic iron deposition, and hepatosplenomegaly.
Topology
Cytoplasmic: 1-207
Helical: 208-228
Vesicular: 229-258
Helical: 259-279
Cytoplasmic: 280-304
Helical: 305-325
Vesicular: 326-358
Helical: 359-379
Cytoplasmic: 380-390
Helical: 391-411
Vesicular: 412-433
Helical: 434-454
Cytoplasmic: 455-488
PTM
Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage occurs at multiple sites in a glycosylation-independent manner.
Glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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