Rabbit Anti-STEAP3 Recombinant Antibody (CBXS-1648) (CBMAB-S4497-CQ)

Name: Rabbit Anti-STEAP3 Recombinant Antibody (CBXS-1648)
SKU: CBMAB-S4497-CQ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Rabbit

Clone

CBXS-1648

Application

WB, IF

Specificity

Rat, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

STEAP3 Metalloreductase

Introduction

This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

Human	55240
Rat	170824

UniProt ID

Human	Q658P3
Rat	Q5RKL5

Alternative Names

AHMIO2; STMP3; TSAP6; dudlin-2; dudulin-2; pHyde

Function

Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe3+ to Fe2+. Can also reduce of Cu2+ to Cu1+, suggesting that it participates in copper homeostasis. Uses NADP+ as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.

Biological Process

Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process cell cycleIEA:UniProtKB-KW
Biological Process copper ion importManual Assertion Based On ExperimentIBA:GO_Central
Biological Process iron ion homeostasisIEA:UniProtKB-KW
Biological Process protein secretionManual Assertion Based On ExperimentIDA:MGI
Biological Process transferrin transportTAS:Reactome

Cellular Location

Endosome membrane
Localizes to vesicular-like structures at the plasma membrane and around the nucleus.

Involvement in disease

Anemia, hypochromic microcytic, with iron overload 2 (AHMIO2):
A hematologic disease characterized by abnormal hemoglobin content in the erythrocytes which are reduced in size, severe anemia, erythropoietic hyperplasia of bone marrow, massive hepatic iron deposition, and hepatosplenomegaly.

Topology

Cytoplasmic: 1-207
Helical: 208-228
Vesicular: 229-258
Helical: 259-279
Cytoplasmic: 280-304
Helical: 305-325
Vesicular: 326-358
Helical: 359-379
Cytoplasmic: 380-390
Helical: 391-411
Vesicular: 412-433
Helical: 434-454
Cytoplasmic: 455-488

PTM

Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage occurs at multiple sites in a glycosylation-independent manner.
Glycosylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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