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Rabbit Anti-STIM2 Recombinant Antibody (CBXS-1335) (CBMAB-S4193-CQ)

This product is a rabbit antibody that recognizes STIM2. The antibody CBXS-1335 can be used for immunoassay techniques such as: WB.
See all STIM2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXS-1335
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1.394 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Stromal interaction molecule 2
Introduction
This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing.
Entrez Gene ID
57620
UniProt ID
Q9P246
Alternative Names
Stromal interaction molecule 2
Function
Plays a role in mediating store-operated Ca2+ entry (SOCE), a Ca2+ influx following depletion of intracellular Ca2+ stores. Functions as a highly sensitive Ca2+ sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca2+-influx. Regulates basal cytosolic and endoplasmic reticulum Ca2+ concentrations. Upon mild variations of the endoplasmic reticulum Ca2+ concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca2+ release-activated Ca2+ (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca2+ influx.
Biological Process
Biological Process activation of store-operated calcium channel activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular calcium ion homeostasisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of calcium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process store-operated calcium entryManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Endoplasmic reticulum membrane
Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca2+ concentration.
Topology
Extracellular: 15-218
Helical: 219-235
Cytoplasmic: 236-746
PTM
Glycosylated.
Phosphorylated predominantly on Ser residues.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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