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Rabbit Anti-STOML2 Recombinant Antibody (D5N4E) (CBMAB-CP2479-LY)

The product is antibody recognizes STOML2. The antibody D5N4E immunoassay techniques such as: WB,IF (ICC).
See all STOML2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
D5N4E
Antibody Isotype
IgG
Application
WB, IF (ICC)

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu346 of human SLP-2 protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
stomatin like 2
Entrez Gene ID
30968
UniProt ID
Q9UJZ1
Function
Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation.
Biological Process
Biological Process CD4-positive, alpha-beta T cell activationISS:UniProtKB
Biological Process cellular calcium ion homeostasisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process lipid localizationISS:UniProtKB
Biological Process mitochondrial calcium ion transmembrane transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitochondrial protein processingISS:UniProtKB
Biological Process mitochondrion organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of cardiolipin metabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of interleukin-2 productionISS:UniProtKB
Biological Process positive regulation of mitochondrial DNA replicationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of mitochondrial membrane potentialManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein complex oligomerizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process proton motive force-driven mitochondrial ATP synthesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process stress-induced mitochondrial fusionISS:UniProtKB
Biological Process T cell receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Mitochondrion
Mitochondrion inner membrane
Mitochondrion intermembrane space
Membrane raft
Cytoplasm, cytoskeleton
Behaves as an integral membrane protein of the mitochondrion despite the absence of a detectable transmembrane domain (PubMed:21746876).
Also associates with the actin cytoskeleton and membrane rafts in activated T-cells (PubMed:18641330, PubMed:10713127).
A minor pool is associated with the plasma membrane and is enriched at the immunological synapse in activated T-cells (PubMed:22623988).
PTM
Hyperphosphorylated at Ser-17 in some patients with monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma (MM) and Waldenstrom macroglobulinemia due to impaired dephosphorylation by PP2A.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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